姓名：陈雪冰
职称：教授
导师：硕导
专业：有机化学
研究方向：有机合成化学
n 教育经历
2009.09-2014.07 云南大学 有机化学 研究生/博士
2005.09-2009.07 云南大学 应用化学 本科/学士
n 工作经历
2023.11-至今 红河学院化学与资源工程学院 教授
2018.10-2023.10 红河学院化学与资源工程学院 副教授
2014.08-2018.09 红河学院理学院 讲师
n 教学
本科生课程《有机化学I/II》、《化学设计实验》、《食品生物化学》、《仪器分析实验》、《药物化学及制剂技术》
n 奖励与荣誉
云南省第十六届职工职业技能大赛，主讲《有机化学》比赛获“二等奖”，2019.12，云南省高等学校教师教育联盟“技术能手”，2020.8，云南省职工经济技术创新工程领导小组
n 研究项目
苯并氮杂卓类杂环化合物的合成及其抗菌活性研究，云南省科技厅应用基础研究青年项目，2016.07-2019.06，项目主持人
基于2-氨基-4-喹啉酮区域选择性反应的氮杂环化合物的合成及其抗肿瘤活性研究，云南省地方高校联合专项-面上项目，2021.11-2024.11，项目主持人
n 代表性成果
(1) Mingshuai Zhang, Meichen Liu, Yuetong Qiu, Menglin Peng, Zhilai Zhang, Siyu Song, Xue-Bing Chen,* Fuchao Yu.* Silver-catalyzed Cascade Bis-heteroannulation Reaction of Enynones and o-Hydroxyphenyl Enaminones: Access to Highly Functionalized 3-Furylmethyl Chromones. Advanced Synthesis & Catalysis, 2024, 366, 2363– 2369.
(2) Qi Yang, Shuntao Huang, Lu Yin, Zhuoyu Wang, Xuebing Chen,* Chao Huang*. NBS-Promoted Synthesis of Thiocyanated Aminomaleimides and Site-Selective Intramolecular Cyclization Access to 1,4- Benzothiazepines via S−CN Bond Cleavage. The Journal of Organic Chemistry, 2024, 89, 5266−5276.
(3) Yulin Sun, Zhuoyuan Liu, Donghan Liu, Mingshuai Zhang, Longkun Chen, Zhangmengjie Chai, Xue-Bing Chen,* Fuchao Yu*. Synthesis of 4‑Alkylated 1,4-Dihydropyridines: Fe(II)-Mediated Oxidative Cascade Cyclization Reaction of Cyclic Ethers with Enaminones. The Journal of Organic Chemistry, 2023, 88, 11627−11636.
(4) Zhuoyuan Liu, Yulin Sun, Mingshuai Zhang, Longkun Chen, Xue-Bing Chen,* Xiang Li*, Fuchao Yu *. Fe-mediated oxidative cascade [1+2+3]-cyclization/esterification reaction: synthesis of 4-alkylated 1,4-dihydropyridines. Organic & Biomolecular Chemistry, 2023, 21, 5475–5480.
(5) Qi Yang, Shuntao Huang, Lu Yin, Zhuoyu Wang, Xuebing Chen*, Chao Huang*. Microwave-assisted DABCO-promoted regioselective [3 + 3] tandem cyclization: synthesis of pyrrolo[3,4-b]pyridine-4-ones fromtrifluoromethyl-alkynyl esters and α-aminomaleimide. Organic & Biomolecular Chemistry, 2023, 21, 6039–6045.
(6) Mingshuai Zhang, Zhuoyuan Liu, Longkun Chen, Donghan Liu, Yulin Sun, Zhangmengjie Chai, Xue-Bing Chen,* Fuchao Yu*. Synthesis of Functionalized 3-(1H-Isochromen)-chromones via Ag2O-Catalyzed Cascade Cyclization Reaction of o-Hydroxyarylenaminones with o-Alkynylbenzaldehydes. Advanced Synthesis & Catalysis, 2022, 364, 4440– 4446.
(7) Xue-Bing Chen*, Shun-Tao Huang, Jie Li, Qi Yang, Fuchao Yu*. Highly Regioselective and Chemoselective [3+3] Annulation of Enaminones with ortho-Fluoronitrobenzenenes: Divergent Synthesis of Aposafranones and Their N‑Oxides. Organic Letters, 2021, 23, 3032-3037.
(8) Zhao Yu, Chen Zhuo, Chen Xuebing*. Synthesis of 2-Quinolinone Derivatives via [3+3] Cyclization Promoted by Acetic Anhydride. Chinese Journal of Organic Chemistry, 2021, 41, 731-737.
(9) Yan Lijun, Yan Yuxin, Chen Xuebing*, Wang Yongchao*. Advances in Multicomponent Asymmetric Cascade Synthesis Involving Hydrogen-Bond-Activated Nitroolefins. Chinese Journal of Organic Chemistry, 2020, 40, 856-872.
(10) Xue-Bing Chen*, Sheng-Li Xiong, Zhi-Xu Xie, Yong Chao Wang, Wei Liu*. Three-Component One-Pot Synthesis of Highly Functionalized Bis-Indole Derivatives. ACS Omega, 2019, 4, 11832−11837.
(11) Hairui Bai, Rongrong Sun, Shitao Liu, Lijuan Yang, Xuebing Chen,* Chao Huang*. Construction of Fully Substituted 2‑Pyridone Derivatives via Four-Component Branched Domino Reaction Utilizing Microwave Irradiation. The Journal of Organic Chemistry., 2018, 83, 12535−12548.
(12) Xue-Bing Chen*, Jia-Wu Gong, Xu-Dong Zhang, Xiu-Lai Liu, Wei Liu*, Yong-Chao Wang*. Catalyst-free concise synthesis of multi-functional 3-cyano-4-quinolinone derivatives from cyanoacetylenaminones and DMF-DMA. Tterahedron 2018, 74, 401‒406.
(13) Fu-Jun Liu(学生), Tian-Tian Sun, Yun-Gang Yang, Chao Huang, Xue-Bing Chen*. Divergent synthesis of dual 1,4-dihydropyridines with different substituted patterns from enaminones and aldehydes through domino reactions. RSC Advances, 2018, 8, 12635‒12640.
(14) Xue-Bing Chen*, Xue-Quan Wang, Jia-Na Song, Qing-Li Yang, Chao Huang*, Wei Liu*. Efficient construction of C–N and C–S bonds in 2-iminothiazoles via cascade reaction of enaminones with potassium thiocyanate. Organic & Biomolecular Chemistry., 2017, 15, 3611‒3615.
(15) Xue-Bing Chen*, Xue-Quan Wang, Yong Hong, Wei Liu*. Site-Selective Convergent Synthesis of Spiroacridines through a Cascade Reaction of Enaminones with Acenaphthoquinone: An Efficient Construction of Multiple C–C and C–Heteroatom Bonds. Asian Journal of Organic Chemistry, 2016, 5, 907‒913.
(16) Xue-Bing Chen, Zhi-Cheng Liu, Xin-Rong Lin, Rong Huang, Sheng-Jiao Yan*, Jun Lin*. Highly diastereoselective convergent synthesis of polycyclic pyrroles with consecutive quaternary stereocenters: cascade construction of multiple C−C and C−hetero bonds. ACS Sustainable Chemistry & Engineering, 2014, 2, 2391‒2398.
(17) 陈雪冰, 汪学全, 刘卫, 洪涌. 一种喹啉类烯胺酮化合物及其制备方法. 发明专利, 专利号：ZL201610877398.6.
